PRINCIPAL INVESTIGATOR Dr. Virendra Singh, Assistant Professor

School of Biotechnology, JNU, New Delhi, DL 110067 IN

singhvirendra@live.com, virendrasingh@mail.jnu.ac.in

PRINCIPAL INVESTIGATOR Dr. Virendra Singh, Assistant Professor

School of Biotechnology, JNU, New Delhi, DL 110067 IN

singhvirendra@live.com, virendrasingh@mail.jnu.ac.in

Why Our Lab

Despite huge research on cancer during last five decades, a lacunae in patient care still exists, especially in aspects of quality of life of patients. Reason being, the side effects of ‘one-size-fits-all’ strategy of available cancer therapeutics. Recently, it is emerged that cancer outcome in patients are not uniform and different patients of a particular cancer type have different molecular events responsible for these varied consequences. The term 'personalized therapeutics' or 'precision medicine' evidently categorizes patients according to their genotype-phenotype profiles that dictates individual treatment options. We are engaged in applying available data science methods on cancer data sets of gene expression, methylation, mutation, genetic variations and non-coding RNAs, which are previously published or newly generated by us. Our group is doing all this to deduce better diagnostics and therapeutics for cancer.

Collaborators

Prof. Rana P. Singh

School of Life Sciences

Jawaharlal Nehru University (JNU)

New Delhi, India

Prof. Pawan K. Dhar

Dean, School of Biotechnology

Jawaharlal Nehru University (JNU)

New Delhi, India

Prof. Savita Yadav

Department of Biophysics

All India Institute of Medical Sciences (AIIMS)

New Delhi, India

Prof. B. C. Koner

Department of Biochemistry

Maulana Azad medical College

New Delhi, India

Publications

Sinha A, Singh V, Tandon R, Srivastava LM. Dichotomy of Complement System: Tumorigenesis or Destruction. Accepted for publication in Immunology Letters .
Singh V, Singh R, Kujur PK, Singh RP. Combination of Resveratrol and Quercetin Causes Cell Growth Inhibition, DNA Damage, Cell Cycle Arrest and Apoptosis in Oral Cancer Cells. Accepted for publication in Assay and Drug Development Technologies.
Sinha A, Singh V, Singh S, Yadav S. Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males. Life Sci. 2019 Feb 1;218:81-88. doi: 10.1016/j.lfs.2018.12.016.
Singh V, Singh AP, Sharma I, Singh LC, Sharma J, Borthakar BB, Rai AK, Kataki AC, Kapur S, Saxena S. Epigenetic deregulations of Wnt/β-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation. J Cancer Res Ther. 2019 Jan-Mar;15(1):192-203. doi: 10.4103/jcrt.JCRT_634_17.
Sinha A, Singh V, Yadav S. Multi-omics and male infertility: status, integration and future prospects. Front Biosci (Schol Ed). 2017 Jun 1;9:375-394.
Singh V, Singh LC, Singh AP, Sharma J, Borthakur BB, Debnath A, Rai AK, Phukan RK, Mahanta J, Kataki AC, Kapur S, Saxena S. Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population. Am J Cancer Res. 2015 Feb 15;5(3):979-99. eCollection 2015.
Singh V, Singh LC, Vasudevan M, Chattopadhyay I, Borthakar BB, Rai AK, Phukan RK, Sharma J, Mahanta J, Kataki AC, Kapur S, Saxena S. Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population. OMICS. 2015 Nov;19(11):688-99. doi: 10.1089/omi.2015.0121.
Katiyar S, Balani S, Singh V. Novel lymphoblastoid cell lines from primary neoplasms of the upper aero-digestive tract. Indian J Med Res. 2012 Jun;135(6):803-5.
Singh V, Upadhyay G, Rastogi N, Singh K, Singh MP. Polymorphism of xenobiotic-metabolizing genes and breast cancer susceptibility in North Indian women. Genet Test Mol Biomarkers. 2011 May;15(5):343-9. doi: 10.1089/gtmb.2010.0197.
Singh C, Shyanti RK, Singh V, Kale RK, Mishra JPN, Singh RP. Integrin expression and glycosylation patterns regulate cell-matrix adhesion and alter with breast cancer progression. Biochem Biophys Res Commun. 2018 May 5;499(2):374-380. doi: 10.1016/j.bbrc.2018.03.169.
Singh V, Rastogi N, Sinha A, Kumar A, Mathur N, Singh MP. A study on the association of cytochrome-P450 1A1 polymorphism and breast cancer risk in north Indian women. Breast Cancer Res Treat. 2007 Jan;101(1):73-81
Singh V, Rastogi N, Mathur N, Singh K, Singh MP. Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women. Ann Epidemiol. 2008 Jan;18(1):48-57
Singh V, Parmar D, Singh MP. Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?Cancer Invest. 2008 Oct;26(8):769-83. doi: 10.1080/07357900801953196
Yadav S, Singhal NK, Singh V, Rastogi N, Srivastava PK, Singh MP. Association of single nucleotide polymorphisms in CYP1B1 and COMT genes with breast cancer susceptibility in Indian women. Dis Markers. 2009;27(5):203-10. doi: 10.3233/DMA-2009-0663.
Patel S, Singh V, Kumar A, Gupta YK, Singh MP. Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. Brain Res. 2006 Apr 7;1081(1):9-18.

V. Singh's Laboratory of Precision Medicine Research

V. Singh's Laboratory of Precision Medicine Research

PRINCIPAL INVESTIGATOR Dr. Virendra Singh, Assistant Professor

PRINCIPAL INVESTIGATOR Dr. Virendra Singh, Assistant Professor

CURRENT AND FUTURE AREAS OF RESEARCH

Why Our Lab

Collaborators

Publications

Contact Us

Dr. Virendra Singh, Assistant Professor